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I would try building up a vbs script that
1. deletes out all the hives under HKEY_USERS that are not the standard Default users...
2. deletes all files under Documents & Settings (except for the defaults)
I would have thought that would be feasible.
Once you have a working vbs, create your LANDesk package and set it as a recurring scheduled task on the machines you need to clean up.
I'm not much help with the scripting, I'm afraid, but would be interested to see what you find.
Thanks for the pointer, I will look into a VB script and do some testing.
I am currently using Delprof, this needs to be run as an administrator on the machine, I need to run this remotely during the silent hours without the need to visit the machines. I am using a batch file with a text file with all asset names but it fails to run on 50% of the machines, therefore I am trying to find a more reliable process to delete the profiles.