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In terms of identifying things more granular using queries(if i am understanding your question correctly) you can use regular expressions to do so - http://www.droppedpackets.org/systemmanagement/ldms/reports/use-regular-expressions-in-queries/
In terms of the IE settings or other things, you can have LANDesk pull in any registry key or other variables by extending the inventory scanning by way of custom inventory. This doc goes into it and data modeling as an example - http://community.landesk.com/support/docs/DOC-2538
If you need to just check for a reg key or file, etc... you can also use a custom definition in the patch manager..
Hope this helps...