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If you know exactly what you want to remove (or at least from what point) you can create a new attribute on your Note object that uses a calculation to strip out just the text you want. You would create this as a BeforeSave calculation with a dependency on the original Text attribute.
You will have to get to grips with using the Substring(), IndexOf(), etc. functions if you're not familiar with them. This tutorial should give some ideas: Calculation Writing Tutorial - 6. Working with Strings.
I am not to hot on manipulating text using strings the logic escapes me, are there any examples of a calculation that identifes a specific string of text and removes it.