We have had several issues with the two 10.10 patches for the LANDesk agent. I have a ticket open and have been told that they should have a fix soon, possibly this week. The AV issues specifically are Kaspersky support for 10.10, which is also being resolved.
OK we have an update "https://community.landesk.com/support/docs/DOC-33061"
After initial install Kaspersky still does not work! At this point in time we are see the inventory scanner work as expected it actually shows progress when scanning.
AV appears to be running when you do a ps ax | grep LANDesk. However these is still no "K" in the quick launch bar. You also cannot see this device in Management suite