this is an interesting point because as far as I know, .NET 4.6 isn't supported yet but Windows 10 as a console platform is. And you are right, 4.6 is integrated in Windows 10 and not removable. I would suggest to open a ticket with LANDESK Support.
Thanks. After speaking with support, I realized that End Point Protection was blocking the .exe. After fixing that, all worked as normal.