ISM does not natively support MFA, however if you want that you could log a feature request via the User Voice portal (info below).
MFA might be accomplished if implemented on the login page for an external auth provider such as ADFS, however, that configuration would be entirely outside of the ISM product. There's certainly some interesting results when I google for the idea:
====================================================================================================The functionality that you are looking for is not currently available in the product. Our product management teams are always looking for new ideas to help us improve our products and we know the best ideas come from customers that use our products every day.
We would therefore encourage that you consider submitting a suggestion in our Feature Request portal via the Ivanti Community Ideas homepage
You can submit ideas and show support for ideas that other customers have submitted by voting for them. The more votes an idea receives, the more visibility it receives with our Product Management team. The Product Management team will evaluate all ideas that reach a voted point threshold. When there is an update on the status, an Ivanti product manager will reply to the idea or update the status so that all interested parties are notified. It is therefore key that you as a customer raise new or vote on exiting ideas to be kept looped in with future progress.
When you create an idea, please describe both the problem or pain you're experiencing as well as your suggested solution to that problem. It can also be useful to describe specifically how you would use the new feature if it were built, as well as how you are dealing with the problem today. The better your explanation and logic, the better your chances of attracting positive votes from other users and ensuring a response from Product Management.
Thanks in advance for your feedback.
Ivanti Community Ideas Homepage: https://community.ivanti.com/community/enhancementrequests