You could create a batch file or other script as a dependant package that sends pskill or other task killer to close Office Applications.
I would tackle this with a script that would check if the Office apps are running and then display a message asking the user to close them. After a wait of a few minutes I would assume the install is happening at a time when the user is not present and would do a taskkill to terminate the apps and then start the install.
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I'm using an HTA application to prompt the user that all work needs to be saved and applications need to be closed. Once they click an OK button, the vbscript will end any running Office processes and then start the installation. Downside to this approach is that your interrupting the user and waiting for them to click "OK".
If you can run the installation after hours, I would just use a script or batch file to drive the installation and kill running processes using taskkill as the others suggested, or use vbscript to end processes.