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It would be virtually impossible to determine the operational conditions that would dictate whether a machine needs to be rebooted based on a locked file. LANDesk would have to track each file in a patch, determine if it is locked, then take some action. It is much easier to determine whether a machine needs to be rebooted based on the PendingFileRenameOperations key.
So, it is luck of the draw then? I understand there are millions of variables that could cause the need for a reboot, however I had hoped staging and testing on a wide sample of systems would help me know better if a reboot would happen or not. (Reason being that some systems are only here for a short period of time, and I would like to push or auto fix while they work and go unnoticed and be able to apply more. A reboot gets me 1. Trouble with the user and 2. Unable to "spot fix" these systems that otherwise do not connect with my network often)
Not just patches write to that key - printer drivers, other software, etc.... write to the key for locked files. We create a policy that users run that displays whether a reboot is pending or not.